Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF429242 dihydrochloride 是一种可逆的竞争性 SREBP 位点 1 蛋白酶抑制剂,IC50值为175 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 272 | 现货 | ||
2 mg | ¥ 397 | 现货 | ||
5 mg | ¥ 713 | 现货 | ||
10 mg | ¥ 1,070 | 现货 | ||
25 mg | ¥ 2,280 | 现货 | ||
50 mg | ¥ 3,290 | 现货 | ||
100 mg | ¥ 4,890 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 783 | 现货 |
产品描述 | PF429242 dihydrochloride can reversibly inhibit S1P (IC50 of 175 nM). |
靶点活性 | S1P:175 nM |
体外活性 | 10 μM PF-429242 down-regulates the signal from an SRE-luciferase reporter gene in human embryonic kidney 293 cells and the expression of endogenous SREBP target genes in cultured HepG2 cells. In HepG2 cells, PF-429242 inhibits cholesterol synthesis, with an IC50 of 0.5 μM[1]. PF-429242 treatment also shows suppressive effects on DENV2 yields in the cultured fluids of human-derived HEK-293, Hep G2, and non-human-primate derived LLC-MK2 cells[2]. PF-429242 has potent antiviral against LCMV and LASV [3]. |
体内活性 | PF-429242 inhibits the expression of hepatic SREBP target genes, and the hepatic rates of cholesterol and fatty acid synthesis are reduced In mice[1]. |
分子量 | 482.49 |
分子式 | C25H37Cl2N3O2 |
CAS No. | 2248666-66-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50 mg/mL (103.63 mM), Sonication is recommended.
DMSO: 83.3 mg/mL (165.81 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 2.0726 mL | 10.3629 mL | 20.7258 mL | 51.8145 mL |
5 mM | 0.4145 mL | 2.0726 mL | 4.1452 mL | 10.3629 mL | |
10 mM | 0.2073 mL | 1.0363 mL | 2.0726 mL | 5.1815 mL | |
20 mM | 0.1036 mL | 0.5181 mL | 1.0363 mL | 2.5907 mL | |
50 mM | 0.0415 mL | 0.2073 mL | 0.4145 mL | 1.0363 mL | |
100 mM | 0.0207 mL | 0.1036 mL | 0.2073 mL | 0.5181 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PF429242 dihydrochloride 2248666-66-0 GPCR/G Protein S1P Receptor PF429242 PF-429242 Dihydrochloride PF-429242 dihydrochloride Virus Protease inhibit Inhibitor PF 429242 Dihydrochloride PF-429242 Fatty Acid Synthase (FASN) PF 429242 PF429242 Dihydrochloride inhibitor